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By generating mice with astrocytic or hepatocytic ALDH2 deficiency, Jin and collaborators showed that acetate derived from centralrather than peripheralethanol metabolism primarily drove the synthesis of gamma-aminobutyric acid (GABA), the most common inhibitory neurotransmitter in the brain after low-dose ethanol administration

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We propose that this interference by metformin may be enhanced in individuals with the A allele in the cubilin gene, though mechanistic investigations are needed to prove this